Clues
8-point star
6-point star
Sanctuary
When the "Energy" and "Void" influence was removed, and the eight-pointed star became the six-pointed star, Fire flipped from south to north and Water flipped from north to south. Air and Earth remained east and west, so are stronger. This has impacted on the sanctuary, as the elements are not in balance - Air and Earth have intruded whilst Fire and Water have retreated.
Air and Water are now Life aligned, and Earth and Fire death aligned. Previously, Water and Earth were Life aligned so Air and Fire were Death aligned.
The "Primal Death" has been released, but there must be a "Primal Life" force trapped somewhere. If we could free them then it would re-balance the world until such a time as Artemis could be challenged. It took three agents of the original Gods to challenge Artemis the first time, one Law, one Chaos, and one Neutral. We should expect to find the "Primal Life" force trapped by Air with Fire supporting (based on the original opposed elements, as we found Earth and Water with Artemis).